Fresh analysis indicates that patients who stop using new slimming jabs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who end traditional lifestyle programs.
Research printed in a leading medical journal demonstrates that while obese people often shed a large proportion of their body weight while undergoing treatment, the weight comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"Individuals using such drugs need to be cognizant of the risk of quick weight regain when the therapy concludes," warns expert Dr. Susan Jebb.
That rate of recovery suggests a reversion to starting weight in about 18 months.
Comparing Therapies
The study, which examined dozens of studies involving thousands of patients, compared the results of these new drugs with other pills.
The team emphasize that people who shed pounds through diet and exercise generally experience a slower creep back—perhaps 100 grams monthly—post-intervention.
Explaining the Fast Rebound
Doctors believe the way of the injections explains the accelerated regain.
The injections copy a body's own chemical called GLP-1, which helps regulate appetite.
"Artificially providing the hormone levels far above than normal could lead to the body to produce less of its endogenous hormone, and could reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics expert.
"Stopping of this medication results in appetite is no longer kept in check, making excessive eating much more probable."
A Lifelong Condition?
The NHS recommend the injections for individuals with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals say that, given the significant potential of weight regain, the therapy might need to be ongoing.
This opinion is reinforced by drug manufacturers, who note that the results "underscore the chronic nature of excess weight," similar to managing conditions like hypertension.
Patient Experiences
Individuals who have stopped the jabs describe a intense resurgence of cravings.
"It was like a switch activating and you're instantly ravenous," recalled a patient.
This challenge is exacerbated if users have not adopted permanent dietary or behavioural modifications during treatment.
Growing Interest
Recent estimates suggest that millions of people in the UK have used these injections in the past year, with demand being substantial.
- Adoption is more common among females compared to males.
- The 40s and 50s age group shows the highest level of interest.
- A large proportion access the drugs through private healthcare rather than the NHS.
Finally, researchers stress that while these medications are potent tools for weight loss, they are not a permanent cure and lasting health benefits hinges on ongoing behavioural support.
